No.PISchemeRef.PeriodTitleFunded amountCurrency
1Dr. LIU, JinRGC-GRF1210692401/09/2024-31/03/2027Targeting osteoblastic 11β-HSD1 to combat high fat diet-induced bone loss, glucose handing impairment and obesity1,559,514HKD
2Prof. ZHANG GeITFGHP/149/21GD03/10/2023-26/01/2025Development of Small-molecule Inhibitors Targeting Sclerostin Loop3 for Osteoporosis1,999,850HKD
3Prof. ZHANG GeITFPiH/356/2303/10/2023-26/01/2025Development of Small-molecule Inhibitors Targeting Sclerostin Loop4 for Osteoporosis733,838.71HKD
4Prof. ZHANG GeITFPiH/466/2315/09/2023-31/03/2025Development of Small-molecule Inhibitors Targeting Sclerostin Loop5 for Osteoporosis846,450.00HKD
5Prof. ZHANG GeITFPiH/432/2301/09/2023-31/08/2024Development of Small-molecule Inhibitors Targeting Sclerostin Loop6 for Osteoporosis558,000.00HKD
6Prof. ZHANG, GeRGC-GRF1210222301/01/2024-31/12/2026Macrophagic sclerostin loop2-ApoER2 interaction participates in the suppressive effect of sclerostin on atherosclerosis1,598,500HKD
7Prof. ZHANG, GeRGC-GRF1210092101/01/2022-30/06/2025A next generation of sclerostin inhibitor with bone anabolic potential and without increasing cardiovascular risk for osteogenesis imperfecta: How does sclerostin loop3-specific aptamer work?1,159,228HKD
8Prof. ZHANG, GeRGC-GRF1210252401/01/2025-31/12/2027Osteoblastic sclerostin loop3-LRP4 interaction could be required by sclerostin to inhibit bone formation1,364,633HKD
9Prof. ZHANG, Ge深港澳科技计划SGDX2023082109535900224/05/2024-23/05/2026硬骨抑素特定结构区loop3在模拟失重导致的骨形成降低和区域性动脉僵硬度升高中的功能研究3,000,000HKD
10Prof. ZHANG, Ge广东省基础与应用基础研究基金项目2019B151512008901/01/2020-31/12/2022骨硬化素loop3适配子的促骨形成潜能:分子机理及转化研究1,000,000HKD
11Dr. YU SifanNFSC8230437801/01/2024-31/12/2026Studies on the mechanism of long-lasting modification combined two small molecules: taking the dual-modified sclerostin apatmer as an example300,000RMB
12Prof.LYU, AipingTRST12-201/20-R01/01/2021 - 31/12/2025Aptamer: Molecular Insight & Translational Theranostics  
13Dr YU, YuanyuanRGC-GRF1210212001/01/2021 - 30/06/2023Targeting sclerostin loop3 to promote bone formation with low cardiovascular risk in animal models  
14Dr YU, YuanyuanRGC-GRF1210232201/01/2023 - 31/12/2025The role of the interactions between N domain and Linker 2 of DKK1 in modulating the immunosuppressive tumor microenvironment mediated by DKK1 C domain  
15Dr. WANG LuyaoNSFC8230098801/01/2024-31/12/2026Macrophagic sclerostin loop2-ApoER2 interaction required by sclerostin for atherosclerosis suppressive action